The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Feb. 11, 2013
Applicant:
Xencor, Inc., Monrovia, CA (US);
Inventors:
Gregory Alan Lazar, Indianapolis, IN (US);
Wei Dang, Pasadena, CA (US);
John Desjarlais, Pasadena, CA (US);
Sher Bahadur Karki, Santa Monica, CA (US);
Omid Vafa, Monrovia, CA (US);
Robert Hayes, Paoli, PA (US);
Jost Vielmetter, Altadena, CA (US);
Assignee:
Xencor, Inc., Monrovia, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C07K 1/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); C07K 16/2863 (2013.01); C07K 16/2893 (2013.01); C07K 16/283 (2013.01); C07K 16/2887 (2013.01); C07K 16/32 (2013.01); C07K 2317/14 (2013.01); C07K 2317/41 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/34 (2013.01);
Abstract
The present invention relates to a variant Fc region comprising an amino acid substitution at position 238 of the Fc region as compared to a human parent Fc region, wherein the variant Fc region comprises a 238D substitution, wherein the variant Fc region binds FcγRIIb with increased binding affinity compared to a human parent Fc region.