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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9051279 B1

PDFFull Text
Date of Patent:
Jun. 09, 2015

Filed:

Feb. 27, 2013

Substituted isoquinolinones and quinazolinones

Applicant:

Novartis Ag, Basel, CH;

Inventors:

Joerg Berghausen, Lorrach, DE;

Nicole Buschmann, Basel, CH;

Pascal Furet, Thann, FR;

Francois Gessier, Altkirch, FR;

Joanna Hergovich Lisztwan, Walton-on-Thames, GB;

Philipp Holzer, Sissach, CH;

Edgar Jacoby, Basel, CH;

Joerg Kallen, Basel, CH;

Keiichi Masuya, Basel, CH;

Carole Pissot Soldermann, Village Neuf, FR;

Haixia Ren, Shanghai, CN;

Stefan Stutz, Basel, CH;

Assignee:

Novartis AG, Basel, CH;

Attorney:

Scott W. Reid

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 239/82 (2006.01); A01N 43/54 (2006.01); A61K 31/517 (2006.01); C07D 217/24 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/04 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 239/82 (2013.01); C07D 217/24 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01);
Abstract

The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CHor N—Rand X, R, R, R, R, Rand n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

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