The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2015
Filed:
Jun. 11, 2012
Pengfei Zhang, Zhejiang, CN;
Chao Shen, Zhejiang, CN;
Runpu Shen, Zhejiang, CN;
Wei Liu, Zhejiang, CN;
Chunlei Wu, Zhejiang, CN;
Pengfei Zhang, Zhejiang, CN;
Chao Shen, Zhejiang, CN;
Runpu Shen, Zhejiang, CN;
Wei Liu, Zhejiang, CN;
Chunlei Wu, Zhejiang, CN;
HANGZHOU NORMAL UNIVERSITY, Hangzhou, Zhejiang Province, CN;
UNIVERSITY OF SHAOXING, Shaoxing, Zhejiang Province, CN;
Abstract
The present invention describes a novel synthetic method for preparing the key intermediate 2,6,10-trimethyl-1,1-dialkoxy-3,5,9-undecatriene of lycopene. An existing synthetic method have some disadvantages that it is very difficult to gain the raw material dialkyl 4-methyl-5,5-diakoxy-1-pentene-1-phosphonate (10) because no effective synthetic method can be adopted, and furthermore the obtained target compound is composed of several cis/trans isomers. This invention relates to a process comprising a condensation step wherein a starting C10-phosphonate is changed to its carbanion completely at a temperature of −40˜30 under an atmosphere of a non-reactive gas in an organic solvent catalyzed by base, and then C4-dialkyl is added to undergo Wittig-Horner condensation. This invention affords all trans C14-acetal and this method is characterized with the advantages of simple procedure, easy access to raw material and low cost, which makes it has the value of industrial application.