The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 12, 2015

Filed:

Jan. 10, 2006
Applicants:

Shawn Defrees, North Wales, PA (US);

Henrik Clausen, Holte, DK;

David A. Zopf, Wayne, PA (US);

Caryn Bowe, Doylestown, PA (US);

Susann Taudte, Pennsburg, PA (US);

Michael Felo, Merrimack, NH (US);

Walter S. Willett, Doylestown, PA (US);

Inventors:

Shawn DeFrees, North Wales, PA (US);

Henrik Clausen, Holte, DK;

David A. Zopf, Wayne, PA (US);

Caryn Bowe, Doylestown, PA (US);

Susann Taudte, Pennsburg, PA (US);

Michael Felo, Merrimack, NH (US);

Walter S. Willett, Doylestown, PA (US);

Assignee:

Novo Nordisk A/S, Bagsvaerd, DK;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/14 (2006.01); A61K 38/16 (2006.01); A61K 38/22 (2006.01); C07K 14/575 (2006.01); C07K 14/535 (2006.01); C07K 1/18 (2006.01); C07K 1/107 (2006.01); A61K 47/48 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/535 (2013.01); C07K 1/18 (2013.01); C07K 1/1077 (2013.01); A61K 47/48092 (2013.01); A61K 47/48215 (2013.01); A61K 47/48238 (2013.01); A61K 38/00 (2013.01);
Abstract

The invention relates to methods of preparing and purifying conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are purified using various chromatography methods.


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