The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 2015
Filed:
Mar. 31, 2006
Tetsuo Kase, Osaka, JP;
Akio Kimura, Osaka, JP;
Hiroshi Ueyama, Osaka, JP;
Mizuki Nishihara, Osaka, JP;
Yoko Kisaki, Isa, JP;
Aya Keshi, Osaka, JP;
Tetsuo Kase, Osaka, JP;
Akio Kimura, Osaka, JP;
Hiroshi Kisaki, Osaka, JP;
Hiroyuki Keshi, Osaka, JP;
Hiroshi Ueyama, Osaka, JP;
Mizuki Nishihara, Osaka, JP;
Fuso Pharmaceutical Industries, Ltd., Osaka, JP;
Osaka Prefectural Government, Osaka, JP;
Abstract
An objective of the present invention is to provide methods of producing human collagen molecules that are easy to isolate and purify and that have a structure substantially equivalent to that of a natural collagen molecule, wherein host cells that are transduced with a collagen gene synthesize large amounts of human collagen protein derived from a gene introduced into a high exogenous gene expression vector. Another objective of the present invention is to provide collagen molecules produced by the production methods. The present inventors discovered that a large amount of human collagen hardly contaminated with host cell-derived collagen could be produced, by selecting from various mammalian cells a host cell that has low collagen expression and introducing a collagen gene construct into a vector capable of high exogenous gene expression.