logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9017969 B1

PDFFull Text
Date of Patent:
Apr. 28, 2015

Filed:

Mar. 01, 2012

Sugar-chain modified yeast and method for producing glycoprotein using the same

Applicants:

Hiroko Abe, Kagawa, JP;

Kazuya Tomimoto, Kagawa, JP;

Yasuko Fujita, Kagawa, JP;

Tomoko Iwaki, Kagawa, JP;

Yasunori Chiba, Ibaraki, JP;

Yoshihiro Nakajima, Kagawa, JP;

Kenichi Nakayama, Hokkaido, JP;

Masatoshi Kataoka, Kagawa, JP;

Shouki Yatsushiro, Kagawa, JP;

Shohei Yamamura, Kagawa, JP;

Inventors:

Hiroko Abe, Kagawa, JP;

Kazuya Tomimoto, Kagawa, JP;

Yasuko Fujita, Kagawa, JP;

Tomoko Iwaki, Kagawa, JP;

Yasunori Chiba, Ibaraki, JP;

Yoshihiro Nakajima, Kagawa, JP;

Kenichi Nakayama, Hokkaido, JP;

Masatoshi Kataoka, Kagawa, JP;

Shouki Yatsushiro, Kagawa, JP;

Shohei Yamamura, Kagawa, JP;

Assignee:

National Institute of Advanced Industrial Science and Technology, Tokyo, JP;

Attorney:

McCarter & English

Primary Examiner:

Nancy T Vogel

Int. Cl.
CPC ...
C12P 21/00 (2006.01); C12N 1/19 (2006.01); C12N 1/16 (2006.01); C12N 9/10 (2006.01); C12N 9/34 (2006.01); C12N 9/60 (2006.01); C07K 14/47 (2006.01); C12N 9/24 (2006.01); C12N 15/09 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 14/4726 (2013.01); C07K 2319/03 (2013.01); C12N 1/16 (2013.01); C12N 9/1051 (2013.01); C12N 9/24 (2013.01); C12N 9/2428 (2013.01); C12N 9/2488 (2013.01); C12N 9/60 (2013.01); C12N 15/09 (2013.01); C12Y 204/01109 (2013.01); C12Y 204/01132 (2013.01); C12Y 204/01255 (2013.01); C12Y 302/01003 (2013.01); C12Y 302/01113 (2013.01); C12Y 304/21048 (2013.01); C12Y 304/23025 (2013.01);
Abstract

The present invention provides: genetically modified yeasts such as mutant yeasts having an ability to produce N-linked sugar chains of ManGlcNAcand a decreased ability to produce O-linked sugar chains, mutant yeasts having an ability to produce N-linked sugar chains of ManGlcNAcand further having an ability to produce N-linked sugar chains of GlcNAcManGlcNAc, and mutant yeasts having an increased ability to produce and secrete proteins and an ability to produce N-linked sugar chains of ManGlcNAc; and a method for producing glycoproteins using them.

Find Patent Forward Citations

Loading…