The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 21, 2015
Filed:
Jun. 03, 2011
Muthiah Manoharan, Cambridge, MA (US);
Martin Maier, Cambridge, MA (US);
Muthusamy Jayaraman, Cambridge, MA (US);
Shigeo Matsuda, Cambridge, MA (US);
Narayanannair K. Jayaprakash, Cambridge, MA (US);
Kallanthottathil G. Rajeev, Cambridge, MA (US);
Akin Akinc, Cambridge, MA (US);
Thomas A. Baillie, Seattle, WA (US);
Muthiah Manoharan, Cambridge, MA (US);
Martin Maier, Cambridge, MA (US);
Muthusamy Jayaraman, Cambridge, MA (US);
Shigeo Matsuda, Cambridge, MA (US);
Narayanannair K. Jayaprakash, Cambridge, MA (US);
Kallanthottathil G. Rajeev, Cambridge, MA (US);
Akin Akinc, Cambridge, MA (US);
Thomas A. Baillie, Seattle, WA (US);
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.