The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 14, 2015
Filed:
Jun. 14, 2006
Daniel G. Anderson, Framingham, MA (US);
Andreas Zumbuehl, Cambridge, MA (US);
Elizaveta Sergeyevna Leshchiner (Turkhanova), Watertown, MA (US);
Robert S. Langer, Newton, MA (US);
Michael Goldberg, Cambridge, MA (US);
Daniel G. Anderson, Framingham, MA (US);
Andreas Zumbuehl, Cambridge, MA (US);
Elizaveta Sergeyevna Leshchiner (Turkhanova), Watertown, MA (US);
Robert S. Langer, Newton, MA (US);
Michael Goldberg, Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.