The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
May. 08, 2014
Applicant:
Howard University, Washington, DC (US);
Inventors:
Harpal S. Mangat, Potomac, MD (US);
Pradeep K. Karla, Arlington, VA (US);
Assignee:
Howard University, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/00 (2006.01); A61K 31/4178 (2006.01); C07D 405/12 (2006.01); A61K 45/06 (2006.01); A61K 38/05 (2006.01); A61K 31/13 (2006.01); A61K 31/40 (2006.01); A61K 31/5513 (2006.01); A61K 31/5517 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4178 (2013.01); C07D 405/12 (2013.01); A61K 45/06 (2013.01); A61K 38/05 (2013.01); A61K 31/13 (2013.01); A61K 31/40 (2013.01); A61K 31/5513 (2013.01); A61K 31/5517 (2013.01);
Abstract
A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.