The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2015
Filed:
Jul. 20, 2007
Brian Seed, Boston, MA (US);
Jia Liu Wolfe, Winchester, MA (US);
Glen S. Cho, Brookline, MA (US);
Chia-iun Tsai, Winchester, MA (US);
Brian Seed, Boston, MA (US);
Jia Liu Wolfe, Winchester, MA (US);
Glen S. Cho, Brookline, MA (US);
Chia-Iun Tsai, Winchester, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention provides methods and compositions for treating various diseases through selective killing of targeted cells using a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting moiety and, a modifiable activation moiety which is activated by an activation moiety not naturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population.