The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2015
Filed:
Dec. 01, 2011
Makoto Koizumi, Tokyo, JP;
Yasuhide Hirota, Tokyo, JP;
Makiko Nakayama, Tokyo, JP;
Mika Ikeda, Tokyo, JP;
Makoto Koizumi, Tokyo, JP;
Yasuhide Hirota, Tokyo, JP;
Makiko Nakayama, Tokyo, JP;
Mika Ikeda, Tokyo, JP;
Daiichi Sankyo Company, Limited, Tokyo, JP;
Abstract
It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5'-end of the antisense strand and the 3′-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.