The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Sep. 19, 2008
Daniel B. Kim-shapiro, Winston-Salem, NC (US);
S. Bruce King, Walnut Cove, NC (US);
Daniel A. Sweeney, Laurel, MD (US);
Mark T. Gladwin, Garrett Park, MD (US);
Daniel B. Kim-Shapiro, Winston-Salem, NC (US);
S. Bruce King, Walnut Cove, NC (US);
Daniel A. Sweeney, Laurel, MD (US);
Mark T. Gladwin, Garrett Park, MD (US);
Wake Forest University Health Sciences, Winston-Salem, NC (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Abstract
Provided herein are methods of treating hemolysis by administering an active compound in an amount sufficient to treat said hemolysis. It has been found that nitroxyl donors or similar compounds preferentially react with cell-free OxyHb, as compared to OxyHb encapsulated in a red blood cell, and reacts with MetHb to form iron-nitrosyl Hb or nitrite bound MetHb. It has also been found that such compounds reduce cell-free Hb and hemolysis. Active compounds are also contemplated for use in combination therapies, for example, in combination with the administration of red blood cells and/or an agent that promotes hematopoiesis, or in combination with the administration of a nitric oxide donor.