The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Jun. 08, 2006
Ofer Cohen, Moshav Netaim, IL;
Chanoch Kronman, Rehovot, IL;
Baruch Velan, Tel-Aviv, IL;
Avigdor Shafferman, Nes-ziona, IL;
Ofer Cohen, Moshav Netaim, IL;
Chanoch Kronman, Rehovot, IL;
Baruch Velan, Tel-Aviv, IL;
Avigdor Shafferman, Nes-ziona, IL;
Israel Institute for Biological Research, nes Ziona, IL;
Abstract
An organophosphate scavenger is provided, with extended residence time in the mammalian circulation, which can be used in preventive and therapeutic treatment of organophosphate poisoning. The scavenger is a uniformly pegylated serine hydrolase, in which a part of lysine residues were replaced with other residues by site-directed mutagenesis. One part of lysine residues in the hydrolase amino acid sequence is selected for the PEG-coupling, and the other part for the replacement, wherein the selection should ensure that the hydrolase surface shows at least one free amino acid for PEG coupling for all possible views obtained by rotating a 3-D model generated for the hydrolase.