The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2015
Filed:
Oct. 26, 2009
Nagaraj Govindappa, Kodagikere, IN;
Nandini Nataraj, Bangalore, IN;
Sanjay Tiwari, Bangalore, IN;
Partha Hazra, Bangalore, IN;
Mukesh Babuappa Patale, Ausa, IN;
Gokul Jothiraman, Hosur, IN;
Kedarnath Sastry, Bangalore, IN;
Nagaraj Govindappa, Kodagikere, IN;
Nandini Nataraj, Bangalore, IN;
Sanjay Tiwari, Bangalore, IN;
Partha Hazra, Bangalore, IN;
Mukesh Babuappa Patale, Ausa, IN;
Gokul Jothiraman, Hosur, IN;
Kedarnath Sastry, Bangalore, IN;
Biocon Limited, , IN;
Abstract
The present invention relates to novel Prolipase-Bovine trypsinogen (PLBTR) fusion proteins, the genes encoding them, and the production and uses thereof. More specifically, the present invention relates to methods of producing in optimal quantities PLBTR fusion proteins which comprise a heterologous polypeptide which is normally susceptible to autocatalytic activity. More particularly, the present invention relates to fusion proteins which comprise an heterologous polypeptide, such as a serine protease, fused to a lipase signal sequence, which can be expressed by recombinant host cells in desired amounts. The present invention further relates to polynucleotides encoding such fusion proteins, to expression vectors for expression of such fusion proteins, to host cells transformed with such polynucleotides/vectors, and to methods of generating such fusion proteins.