The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2015
Filed:
Oct. 03, 2007
Applicants:
Shawn Defrees, North Wales, PA (US);
Kyle Kinealy, Plymouth Meeting, PA (US);
Inventors:
Shawn DeFrees, North Wales, PA (US);
Kyle Kinealy, Plymouth Meeting, PA (US);
Assignee:
Novo Nordisk A/S, Bagsvaerd, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/18 (2006.01); C07K 1/36 (2006.01); C12P 21/00 (2006.01); A61K 47/48 (2006.01); C07K 1/13 (2006.01); C07K 1/20 (2006.01); C07K 14/00 (2006.01); C07K 17/08 (2006.01); C07K 14/505 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); A61K 47/48215 (2013.01); C07K 1/13 (2013.01); C07K 1/20 (2013.01); C07K 14/00 (2013.01); C07K 14/505 (2013.01); Y10S 930/09 (2013.01);
Abstract
The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.