The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2015
Filed:
Apr. 24, 2013
Applicant:
Regulus Therapeutics Inc., San Diego, CA (US);
Inventors:
Balkrishen Bhat, San Diego, CA (US);
Eric Marcusson, San Francisco, CA (US);
Assignee:
Regulus Therapeutics Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C07H 21/02 (2006.01); C12N 15/113 (2010.01); A61K 31/712 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); A61K 31/712 (2013.01); A61K 45/06 (2013.01); C12N 2310/113 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/343 (2013.01); C12N 2310/346 (2013.01);
Abstract
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer.