The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2015
Filed:
Jun. 01, 2010
Applicants:
Suzanne Walker Kahne, Brookline, MA (US);
Michael Block Lazarus, W. Newton, MA (US);
Benjamin J. Gross, Philadelphia, PA (US);
Inventors:
Suzanne Walker Kahne, Brookline, MA (US);
Michael Block Lazarus, W. Newton, MA (US);
Benjamin J. Gross, Philadelphia, PA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 409/14 (2006.01); C07D 215/36 (2006.01); C07D 417/12 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01); C07D 215/36 (2013.01); C07D 409/14 (2013.01); C07D 405/12 (2013.01); C07D 401/12 (2013.01);
Abstract
The present invention provides inhibitors of O-GIcNAc transferase. Typically, the inhibitors are quinolinone-6-sulfonamides. The invention also provides pharmaceutical compositions thereof and methods for using the same in diabetes and complications thereof, neurodegenerative diseases, cancers, autoimmune diseases, and inflammatory diseases.