The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2015
Filed:
Jun. 24, 2008
Mark F. Oldham, Los Gatos, CA (US);
Kenneth J. Livak, San Jose, CA (US);
Jason E. Babcoke, Suisun City, CA (US);
H. Pin Kao, Fremont, CA (US);
Stephen J. Gunstream, Redwood City, CA (US);
Kevin S. Bodner, Belmont, CA (US);
Douglas P. Greiner, Fremont, CA (US);
Nigel P. Beard, Redwood City, CA (US);
Dar Bahatt, Foster City, CA (US);
Mark F. Oldham, Los Gatos, CA (US);
Kenneth J. Livak, San Jose, CA (US);
Jason E. Babcoke, Suisun City, CA (US);
H. Pin Kao, Fremont, CA (US);
Stephen J. Gunstream, Redwood City, CA (US);
Kevin S. Bodner, Belmont, CA (US);
Douglas P. Greiner, Fremont, CA (US);
Nigel P. Beard, Redwood City, CA (US);
Dar Bahatt, Foster City, CA (US);
Applied Biosystems, LLC, Carlsbad, CA (US);
Abstract
Exemplary embodiments provide microfludic devices and methods for their use. The microfluidic device can include an array of M×N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.