The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2015
Filed:
Aug. 14, 2012
Benjamin F. Cravatt, La Jolla, CA (US);
Kyle P. Chiang, Cardiff, CA (US);
Sherry Niessen, San Diego, CA (US);
Alan Saghatelian, Cambridge, MA (US);
Benjamin F. Cravatt, La Jolla, CA (US);
Kyle P. Chiang, Cardiff, CA (US);
Sherry Niessen, San Diego, CA (US);
Alan Saghatelian, Cambridge, MA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and the lysophospholipids. Biochemical studies confirmed that the active protein regulates this pathway by hydrolyzing the metabolic intermediate 2-acetyl monoalkylglycerol. Inactivation of the active protein disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo.