The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 2015
Filed:
Oct. 23, 2008
Applicants:
Michael C. Holmes, Oakland, CA (US);
Shuyuan Yao, San Diego, CA (US);
Luigi Naldini, Pioltello, IT;
Angelo Leone Lombardo, Sangano, IT;
Inventors:
Michael C. Holmes, Oakland, CA (US);
Shuyuan Yao, San Diego, CA (US);
Luigi Naldini, Pioltello, IT;
Angelo Leone Lombardo, Sangano, IT;
Assignees:
Sangamo BioSciences, Inc., Richmond, CA (US);
Ospedale San Raffaele S.R.L., Milan, IT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/79 (2006.01); C12N 15/87 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 2319/81 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/15045 (2013.01); C12N 2840/203 (2013.01);
Abstract
Disclosed herein are methods and compositions for targeted integration of one or more copies of a sequence of interest using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain and integrase defective lentiviral donor constructs.