The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2015
Filed:
Dec. 28, 2010
Claudia Nardini, Lucca, IT;
Andrea Morelli, Lucca, IT;
Claudio Farina, Pisa, IT;
Sabrina Esposito, Ghivizzano, IT;
Alessandra Lazzarotti, Massa, IT;
Arianna Petrucci, Barga, IT;
Claudia Nardini, Lucca, IT;
Andrea Morelli, Lucca, IT;
Claudio Farina, Pisa, IT;
Sabrina Esposito, Ghivizzano, IT;
Alessandra Lazzarotti, Massa, IT;
Arianna Petrucci, Barga, IT;
Kedrion S.p.A., Barga, IT;
Abstract
The invention relates to a novel, industrial-scale process for the purification of gamma-immunoglobulins (IgG) starting from plasma or fractions thereof. The method involves two chromatographic steps, i.e. a cation exchange capture chromatography, and then a polishing anion exchange chromatography, ensuring a highly purified end product, which contains no aggregates, and high yields. The process also involves a virus inactivation step by means of a solvent/detergent treatment to inactivate the viruses with a lipid envelope, and a virus removal step by nanofiltering to ensure the removal of the non-enveloped viruses.