The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2015
Filed:
Mar. 26, 2010
Mark T. Gladwin, Pittsburgh, PA (US);
Alan N. Schechter, Bethesda, MD (US);
David J. Lefer, Atlanta, GA (US);
Rakesh P. Patel, Hoover, AL (US);
Christian J. Hunter, Boston, MA (US);
Gordon G. Power, Redlands, CA (US);
Daniel B. Kim-shapiro, Winston-Salem, NC (US);
Ryszard Marek Pluta, Bethesda, MD (US);
Edward H. Oldfield, Philomont, VA (US);
Richard O. Cannon, Iii, Potomac, MD (US);
Mark T. Gladwin, Pittsburgh, PA (US);
Alan N. Schechter, Bethesda, MD (US);
David J. Lefer, Atlanta, GA (US);
Rakesh P. Patel, Hoover, AL (US);
Christian J. Hunter, Boston, MA (US);
Gordon G. Power, Redlands, CA (US);
Daniel B. Kim-Shapiro, Winston-Salem, NC (US);
Ryszard Marek Pluta, Bethesda, MD (US);
Edward H. Oldfield, Philomont, VA (US);
Richard O. Cannon, III, Potomac, MD (US);
Abstract
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.