The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2014
Filed:
Dec. 21, 2006
David K. Hanzel, Palo Alto, CA (US);
Geoff Otto, Santa Clara, CA (US);
Paul Peluso, Hayward, CA (US);
Thang Pham, Mountain View, CA (US);
David R. Rank, Palo Alto, CA (US);
Paul Mitsis, Trenton, NJ (US);
Fred Christians, Los Altos Hills, CA (US);
Arek Bibillo, Cupertino, CA (US);
Insil Park, Fremont, CA (US);
Sonya Clark, Oakland, CA (US);
John Lyle, Redwood Shores, CA (US);
David K. Hanzel, Palo Alto, CA (US);
Geoff Otto, Santa Clara, CA (US);
Paul Peluso, Hayward, CA (US);
Thang Pham, Mountain View, CA (US);
David R. Rank, Palo Alto, CA (US);
Paul Mitsis, Trenton, NJ (US);
Fred Christians, Los Altos Hills, CA (US);
Arek Bibillo, Cupertino, CA (US);
Insil Park, Fremont, CA (US);
Sonya Clark, Oakland, CA (US);
John Lyle, Redwood Shores, CA (US);
Pacific Biosciences of California, Inc., Menlo Park, CA (US);
Abstract
Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.