The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 23, 2014

Filed:

Jan. 19, 2012
Applicants:

Marina Caldarelli, Milan, IT;

Francesco Casuscelli, Dairago (MI), IT;

Daniele Donati, Nerviano (MI), IT;

Danilo Mirizzi, Nerviano (MI), IT;

Francesca Quartieri, Arona (NO), IT;

Marco Silvagni, Segrate (MI), IT;

Inventors:

Marina Caldarelli, Milan, IT;

Francesco Casuscelli, Dairago (MI), IT;

Daniele Donati, Nerviano (MI), IT;

Danilo Mirizzi, Nerviano (MI), IT;

Francesca Quartieri, Arona (NO), IT;

Marco Silvagni, Segrate (MI), IT;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61K 31/551 (2006.01); C07D 498/14 (2006.01); C07D 498/04 (2006.01); C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/5383 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 498/14 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01); C07D 498/04 (2013.01); A61K 45/06 (2013.01); A61K 31/519 (2013.01); A61K 31/551 (2013.01);
Abstract

New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare the compounds of formula (I), pharmaceutical compositions containing them, and their use in therapy, in particular for the treatment of diseases caused by and/or associated with dysregulated activity of protein kinase.


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