The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2014
Filed:
Jun. 21, 2013
Rib-x Pharmaceuticals, Inc., New Haven, CT (US);
Yale University, New Haven, CT (US);
Thomas A. Steitz, Branford, CT (US);
Peter B. Moore, New Haven, CT (US);
Joyce A. Sutcliffe, Clinton, CT (US);
Adegboyega K. Oyelere, Hamden, CT (US);
Joseph A. Ippolito, Guilford, CT (US);
Melinta Therapeutics, Inc., New Haven, CT (US);
Yale University, New Haven, CT (US);
Abstract
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.