The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2014
Filed:
Apr. 23, 2007
Martin Friedlander, Del Mar, CA (US);
Atsushi Otani, Otsu, JP;
Karen Da Silva, Irvine, CA (US);
Stacey (Hanekamp) Moreno, Spring Valley, CA (US);
Martin Friedlander, Del Mar, CA (US);
Atsushi Otani, Otsu, JP;
Karen Da Silva, Irvine, CA (US);
Stacey (Hanekamp) Moreno, Spring Valley, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
A method of preserving cone cells in the eye of a mammal suffering from a retinal degenerative disease comprises isolating from the bone marrow of the mammal a lineage negative hematopoietic stem cell population that includes endothelial progenitor cells, transfecting cells from the stem cell population with a gene that operably encodes an antiangiogenic fragment of human tryptophanyl tRNA synthetase (TrpRS), and subsequently intravitreally injecting the transfected cells into the eye of the mammal in an amount sufficient to inhibit the degeneration of cone cells in the retina of the eye. The treatment may be enhanced by stimulating proliferation of activated astrocytes in the retina using a laser.