The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2014
Filed:
Sep. 01, 2003
Aldo Giannozzi, Siena, IT;
Giovanni Averani, Siena, IT;
Francesco Norelli, Siena, IT;
Paolo Costantino, Colle Val Dielsa, IT;
Aldo Giannozzi, Siena, IT;
Giovanni Averani, Siena, IT;
Francesco Norelli, Siena, IT;
Paolo Costantino, Colle Val Dielsa, IT;
Novartis AG, , CH;
Abstract
Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I): -A-N(R)-L-M wherein: A is a bond, —C(O)— or —OC(O)—; R1 is selected from H or C-Calkyl; L is a C-Calkylene group; and M is a masked aldehyde group. The new linker is especially useful for preparing conjugates ofserogroup A saccharide. Conjugates having this new linker have improved immunogenicity compared to other types of conjugates.