The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 11, 2014
Filed:
Jul. 13, 2007
Roland Contreras, Merelbeke, BE;
Nico L. M. Callewaert, Lichtervelde, BE;
Steven C. J. Geysens, Kruishoutem, BE;
Vladimir Kaigorodov, Ghent, BE;
Vervecken Wouter, Gent-Ledeberg, BE;
Roland Contreras, Merelbeke, BE;
Nico L. M. Callewaert, Lichtervelde, BE;
Steven C. J. Geysens, Kruishoutem, BE;
Vladimir Kaigorodov, Ghent, BE;
Vervecken Wouter, Gent-Ledeberg, BE;
Research Corporation Technologies, Inc., Tucson, AZ (US);
Universiteit Gent, Ghent, BE;
Vib, VZW, Zwijnaarde, BE;
Abstract
The present invention provides genetically engineered strains of methylotrophic yeast includingand especiallycapable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains ofare also provided. Vectors, which comprise coding sequences for α-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.