The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 04, 2014

Filed:

Jun. 03, 2008
Applicants:

Michael Steward, Stevenage, GB;

Malgorzata Pupecka, Cambridge, GB;

Ian Tomlinson, Stevenage, GB;

Carolyn Enever, Cambridge, GB;

Laurent Jespers, Cambridge, GB;

Thil Dinuk Batuwangala, Cambridge, GB;

Inventors:

Michael Steward, Stevenage, GB;

Malgorzata Pupecka, Cambridge, GB;

Ian Tomlinson, Stevenage, GB;

Carolyn Enever, Cambridge, GB;

Laurent Jespers, Cambridge, GB;

Thil Dinuk Batuwangala, Cambridge, GB;

Assignee:

Domantis Limited, Brentford, Middlesex, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/22 (2006.01); C07K 14/435 (2006.01); A61K 39/395 (2006.01); C07K 14/475 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); C07K 16/244 (2013.01); C07K 2317/569 (2013.01); C07K 2317/565 (2013.01); C07K 2316/96 (2013.01); C07K 2317/21 (2013.01); C07K 2317/567 (2013.01); C07K 16/2866 (2013.01); C07K 16/22 (2013.01); C07K 2317/92 (2013.01);
Abstract

The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.


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