The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2014
Filed:
Aug. 13, 2010
Applicants:
George N. Pavlakis, Rockville, MD (US);
Barbara K. Felber, Rockville, MD (US);
Antonio Valentin, Frederick, MD (US);
Cristina Bergamaschi, Frederick, MD (US);
Inventors:
George N. Pavlakis, Rockville, MD (US);
Barbara K. Felber, Rockville, MD (US);
Antonio Valentin, Frederick, MD (US);
Cristina Bergamaschi, Frederick, MD (US);
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); A61K 47/48 (2006.01); C07K 14/54 (2006.01); A61K 45/06 (2006.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 38/2086 (2013.01); A61K 47/48423 (2013.01); C07K 14/5443 (2013.01); A61K 48/005 (2013.01); A61K 45/06 (2013.01); A61K 47/48507 (2013.01); A61K 38/1793 (2013.01);
Abstract
The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15.