The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2014
Filed:
Jun. 18, 2013
Applicant:
Biomarin Pharmaceutical Inc., Novato, CA (US);
Inventors:
Jonathan LeBowitz, Novato, CA (US);
Stephen M. Beverley, Clayton, MO (US);
Assignee:
Biomarin Pharmaceutical Inc., Novato, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/30 (2006.01); A61K 38/00 (2006.01); A61K 38/43 (2006.01); A61K 38/46 (2006.01); A61K 47/48 (2006.01); C07K 14/65 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48269 (2013.01); C07K 2319/21 (2013.01); C07K 2319/75 (2013.01); A61K 47/48107 (2013.01); C07K 14/65 (2013.01); C07K 2319/74 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/61 (2013.01); A61K 38/30 (2013.01); A61K 47/48246 (2013.01); C07K 2319/50 (2013.01); C07K 2319/06 (2013.01); C12N 15/62 (2013.01); A61K 47/48276 (2013.01);
Abstract
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.