The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 07, 2014
Filed:
Mar. 24, 2009
Applicants:
Jean-yves Francois Dubois, Saint Beauzire, FR;
Roelof Hendrik Matthijs Kouwen, Groningen, NL;
Jan Maarten Van Dijl, Harkstede, NL;
Inventors:
Jean-Yves Francois Dubois, Saint Beauzire, FR;
Roelof Hendrik Matthijs Kouwen, Groningen, NL;
Jan Maarten Van Dijl, Harkstede, NL;
Assignee:
Danisco US Inc., Palo Alto, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/06 (2006.01); C12N 1/20 (2006.01); C12P 21/02 (2006.01); C12N 15/67 (2006.01); C12N 9/02 (2006.01); C12N 15/75 (2006.01);
U.S. Cl.
CPC ...
C12N 15/67 (2013.01); C12Y 108/01009 (2013.01); C12P 21/02 (2013.01); C12Y 108/01008 (2013.01); C12N 9/0036 (2013.01); C12N 15/75 (2013.01);
Abstract
The invention provides for genetically modifiedhost cells having decreased cytoplasmic reductase activity, such as decreased TrxA activity, and a nucleic acid encoding a heterologous Staphylococcal oxidase. The invention also provides for methods of producing di-sulfide bond containing proteins using the host cells of the invention and methods of improving protein folding using the host cell of the invention.