The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2014
Filed:
Jun. 17, 2009
Marina Caldarelli, Milan, IT;
Mauro Angiolini, Gavirate, IT;
Riccardo Colombo, Oleggio, IT;
Teresa Disingrini, Vanzago, IT;
Stefano Nuvoloni, Genoa, IT;
Helena Posteri, Travedona Monate, IT;
Matteo Salsa, Bellinzago Novarese, IT;
Marco Silvagni, Segrate, IT;
Marina Caldarelli, Milan, IT;
Mauro Angiolini, Gavirate, IT;
Riccardo Colombo, Oleggio, IT;
Teresa Disingrini, Vanzago, IT;
Stefano Nuvoloni, Genoa, IT;
Helena Posteri, Travedona Monate, IT;
Matteo Salsa, Bellinzago Novarese, IT;
Marco Silvagni, Segrate, IT;
Nerviano Medical Sciences S.R.L., Nerviano (MI), IT;
Abstract
The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted-arylamino, heterocyclylamino- or C-Ccycloalkylamino residue at 8 position and an aryl, heterocyclyl or C-Ccycloalkyl as substituent of a carboxamide at 3 position of the molecule framework. The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.