The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2014
Filed:
Nov. 28, 2011
Applicants:
Mamoru Shimizu, Okinawa, JP;
Takeshi Wada, Tokyo, JP;
Kouichiro Arai, Tokyo, JP;
Inventors:
Assignees:
The University of Tokyo, Tokyo, JP;
Chiralgen, Ltd., Okinawa, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 19/10 (2006.01); C07H 23/00 (2006.01); C07H 19/06 (2006.01); C07H 1/00 (2006.01); C07H 19/067 (2006.01); C07H 19/167 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); C07H 19/10 (2013.01); C07H 23/00 (2013.01); C07H 19/06 (2013.01); C07H 1/00 (2013.01); C07H 19/067 (2013.01); C07H 19/167 (2013.01);
Abstract
A 2'-modified ribonucleoside having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. A modified form of RNA having a halogen-substituted alkoxymethyl protective group exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2′-O-methyl modified nucleic acid.