The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2014
Filed:
Jun. 07, 2011
Steven D. Levin, Seattle, WA (US);
Margaret D. Moore, Seattle, WA (US);
Craig D. Ostrander, Bothell, WA (US);
Katherine E. Lewis, Seattle, WA (US);
David W. Taft, Kirkland, WA (US);
Robert J. Rosler, Lynnwood, WA (US);
Anitra Wolf, Puyallup, WA (US);
Megan M. Lantry, Redmond, WA (US);
Steven D. Levin, Seattle, WA (US);
Margaret D. Moore, Seattle, WA (US);
Craig D. Ostrander, Bothell, WA (US);
Katherine E. Lewis, Seattle, WA (US);
David W. Taft, Kirkland, WA (US);
Robert J. Rosler, Lynnwood, WA (US);
Anitra Wolf, Puyallup, WA (US);
Megan M. Lantry, Redmond, WA (US);
ZymoGenetics, Inc., Princeton, NJ (US);
Abstract
Compositions and methods relating to soluble dimeric proteins are disclosed. The dimeric proteins comprise first and second polypeptide fusions linked via a dimerizing domain, each polypeptide fusion comprising first and second monomer domains corresponding to a cytokine or an extracellular domain of a cell-surface receptor. The monomer domains may be positioned amino terminal and carboxyl terminal to the dimerizing domain. Alternatively, the monomer domains may be positioned in tandem, either carboxyl terminal or amino terminal to the dimerizing domain. The dimeric proteins are useful in methods for therapy, diagnosis, and research.