The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Dec. 01, 2006
Bruce D Hammock, Davis, CA (US);
Jiang Zheng, Seattle, WA (US);
Christophe Morisseau, Davis, CA (US);
Kazuhiko Motoba, Kawachinagano, JP;
Mehran F. Moghaddam, San Diego, CA (US);
Babak Borhan, East Lansing, MI (US);
David F. Grant, Storrs, CT (US);
Jessica Greene, Oakland, CA (US);
Marlene F. Sisemore, Davis, CA (US);
James Sanborn, Sacramento, CA (US);
Bruce D Hammock, Davis, CA (US);
Jiang Zheng, Seattle, WA (US);
Christophe Morisseau, Davis, CA (US);
Kazuhiko Motoba, Kawachinagano, JP;
Mehran F. Moghaddam, San Diego, CA (US);
Babak Borhan, East Lansing, MI (US);
David F. Grant, Storrs, CT (US);
Jessica Greene, Oakland, CA (US);
Marlene F. Sisemore, Davis, CA (US);
James Sanborn, Sacramento, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R-Ris hydrogen, Ris hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, Ris hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, Rand Ris each independently C-Csubstituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.