The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Aug. 10, 2009
Nico L. M. Callewaert, Nevele, BE;
Karen DE Pourcq, Ghent, BE;
Steven Geysens, Wannegem-Lede, BE;
Leander Meuris, Ghent, BE;
Nico L. M. Callewaert, Nevele, BE;
Karen De Pourcq, Ghent, BE;
Steven Geysens, Wannegem-Lede, BE;
Leander Meuris, Ghent, BE;
VIB VZW, Ghent, BE;
Universiteit Gent, Ghent, BE;
Abstract
The present application relates to the field of glyco-engineering, more specifically to eukaryotic cells wherein both an endoglucosaminidase and a glycoprotein are present. These cells can be used to deglycosylate or partly deglycosylate the (exogenous) glycoprotein, in particular without the need for adding an extra enzyme. Methods are also provided for the application of these cells in protein production. According to one specific aspect, the eukaryotic cells and methods are glyco-engineered yeast cells in which additionally at least one exogenous enzyme needed for complex glycosylation is present, e.g. allowing easier separation of differentially glycosylated glycoproteins.