The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2014
Filed:
Feb. 10, 2011
Benjamin Cohen, Cranford, NJ (US);
Christopher Wahl, Philadelphia, PA (US);
Itzia Z. Arroyo, Union, NJ (US);
Aaron S. Cote, West Windsor, NJ (US);
Benjamin Cohen, Cranford, NJ (US);
Christopher Wahl, Philadelphia, PA (US);
Itzia Z. Arroyo, Union, NJ (US);
Aaron S. Cote, West Windsor, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
A thermodynamically controlled process for preparing Form I polymorph of lamivudine is described, wherein the process involves crystallizing Form I at a temperature of from about 0° C. to about 50° C. from a mixture which comprises (a) lamivudine or an acid salt thereof or both, (b) a solvent system comprising water and at least one organic solvent, and optionally (c) Form I seed; wherein, when a lamivudine acid salt is employed in the mixture, the crystallizing step is conducted in the presence of a base; and wherein the water activity of the solvent system is maintained in a range in which Form I is thermodynamically the most stable form of lamivudine.