The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2014
Filed:
Mar. 15, 2005
Michael T. Migawa, Carlsbad, CA (US);
Walter F. Lima, San Diego, CA (US);
Eric E. Swayze, Carlsbad, CA (US);
Joshua Nichols, Carlsbad, CA (US);
Hongjiang Wu, Carlsbad, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Tadeusz Krzysztof Wyrzykiewicz, Wyoming, OH (US);
Balkrishen Bhat, Carlsbad, CA (US);
Stanley T. Crooke, Carlsbad, CA (US);
Michael T. Migawa, Carlsbad, CA (US);
Walter F. Lima, San Diego, CA (US);
Eric E. Swayze, Carlsbad, CA (US);
Joshua Nichols, Carlsbad, CA (US);
Hongjiang Wu, Carlsbad, CA (US);
Thazha P. Prakash, Carlsbad, CA (US);
Tadeusz Krzysztof Wyrzykiewicz, Wyoming, OH (US);
Balkrishen Bhat, Carlsbad, CA (US);
Stanley T. Crooke, Carlsbad, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3'hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.