The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2014
Filed:
Nov. 21, 2008
Shigeyuki Yokoyama, Kanagawa, JP;
Kensaku Sakamoto, Kanagawa, JP;
Tatsuo Yanagisawa, Kanagawa, JP;
Takahito Mukai, Kanagawa, JP;
Takatsugu Kobayashi, Kanagawa, JP;
Shigeyuki Yokoyama, Kanagawa, JP;
Kensaku Sakamoto, Kanagawa, JP;
Tatsuo Yanagisawa, Kanagawa, JP;
Takahito Mukai, Kanagawa, JP;
Takatsugu Kobayashi, Kanagawa, JP;
Riken, Saitama, JP;
Abstract
A non-natural protein having at least one ester bond in its polypeptide main chain is synthesized by using an in vivo translation system in a ribosome. The following components (a) to (c) are expressed in a cell or an cell extraction solution in the presence of an α-hydroxy acid: (a) an aminoacyl-tRNA synthetase which can activate the α-hydroxy acid; (b) suppressor tRNA which can bind to the α-hydroxy acid in the presence of the aminoacyl-tRNA synthetase; and (c) a gene encoding a desired protein having a nonsense mutation or a frame-shift mutation at a desired site.