The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2014
Filed:
Jan. 22, 2010
James H. Adair, State College, PA (US);
Mark Kester, Harrisburg, PA (US);
Erhan I. Altinoglu, State College, PA (US);
Brian M. Barth, Hummelstown, PA (US);
Timothy J. Russin, San Diego, CA (US);
James M. D. Kaiser, Harrisburg, PA (US);
Thomas T. Morgan, Pepperell, MA (US);
Karen L. Eklund, Boalsburg, PA (US);
James H. Adair, State College, PA (US);
Mark Kester, Harrisburg, PA (US);
Peter C. Eklund, Boalsburg, PA (US);
Erhan I. Altinoglu, State College, PA (US);
Brian M. Barth, Hummelstown, PA (US);
Timothy J. Russin, San Diego, CA (US);
James M. D. Kaiser, Harrisburg, PA (US);
Thomas T. Morgan, Pepperell, MA (US);
The Penn State Research Foundation, University Park, PA (US);
Abstract
Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.