The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2014
Filed:
Mar. 11, 2011
Debashish Datta, Hyderabad, IN;
Siva Rama Prasad Vellanki, Hyderabad, IN;
Arabinda Sahu, Hyderabad, IN;
Raja Babu Balusu, Hyderabad, IN;
Mastan Rao Ravi, Hyderabad, IN;
Hari Babu Nandipati, Hyderabad, IN;
Shankar Rama, Hyderabad, IN;
Lakshmana Rao Vadali, Hyderabad, IN;
Srikanth Sarat Chandra Gorantla, Hyderabad, IN;
Srinivasa Rao Dasari, Hyderabad, IN;
Nagaraju Mittapelly, Hyderabad, IN;
Debashish Datta, Hyderabad, IN;
Siva Rama Prasad Vellanki, Hyderabad, IN;
Arabinda Sahu, Hyderabad, IN;
Raja Babu Balusu, Hyderabad, IN;
Mastan Rao Ravi, Hyderabad, IN;
Hari Babu Nandipati, Hyderabad, IN;
Shankar Rama, Hyderabad, IN;
Lakshmana Rao Vadali, Hyderabad, IN;
Srikanth Sarat Chandra Gorantla, Hyderabad, IN;
Srinivasa Rao Dasari, Hyderabad, IN;
Nagaraju Mittapelly, Hyderabad, IN;
Mylan Laboratories Limited, Hyderabad, IN;
Abstract
The present invention relates to an improved process for the preparation of Tenofovir Disoproxil and its pharmaceutically acceptable salts comprising the steps of: a) esterifying Tenofovir with chloromethyl isopropyl carbonate in presence of a base, phase transfer catalyst and optionally dehydrating agent, in a suitable solvent; b) optionally purifying Tenofovir Disoproxil; and c) converting of Tenofovir Disoproxil into its pharmaceutically acceptable salts. The present invention further relates to a process for the preparation of Tenofovir by reacting 1-(6-amino-purin-9-yl)-propan-2-ol with toluene-4-sulfonic acid diethoxy phosphoryl methyl ester in presence of a base in a non-polar solvent medium followed by hydrolysis.