The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2014
Filed:
Dec. 16, 2009
Merja E. Penttila, Helsinki, FI;
Michael Ward, San Francisco, CA (US);
Huaming Wang, Fremont, CA (US);
Mari J. Valkonen, Helsinki, FI;
Markku LA Saloheimo, Helsinki, FI;
Merja E. Penttila, Helsinki, FI;
Michael Ward, San Francisco, CA (US);
Huaming Wang, Fremont, CA (US);
Mari J. Valkonen, Helsinki, FI;
Markku La Saloheimo, Helsinki, FI;
Danisco US Inc., Palo Alto, CA (US);
Abstract
Described herein are methods for increasing the amount of protein secreted by a cell. In one case, a cell is provided which contains a heterologous nucleic acid encoding a protein having unfolded protein response modulating activity and a heterologous nucleic acid encoding a protein of interest to be secreted. In one case, the protein having unfolded protein response modulating activity is selected from the proteins selected from the group consisting of HAC1, PTC2 and IRE1. The protein of interest can be any secreted protein such as a therapeutic or an industrial enzyme. For example the protein can be selected from the group consisting of lipase, cellulase, endo-glucosidase H, protease, carbohydrase, reductase, oxidase, isomerase, transferase, kinase, phosphatase, alpha-amylase, glucoamylase, lignocellulose hemicellulase, pectinase and ligninase.