The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2014
Filed:
Jun. 15, 2007
Amy Hauck Newman, Phoenix, MD (US);
Peter Grundt, Duluth, MN (US);
George C. Cyriac, Severna Park, MD (US);
Robert Luedtke, Fort Worth, TX (US);
Jianjing Cao, Ellicott City, MD (US);
Amy Hauck Newman, Phoenix, MD (US);
Peter Grundt, Duluth, MN (US);
George C. Cyriac, Severna Park, MD (US);
Robert Luedtke, Fort Worth, TX (US);
Jianjing Cao, Ellicott City, MD (US);
The United States of America as Represented by the Secretary of the Department of Health and Human Services, Washington, DC (US);
The University of North Texas Health Science Center at Fort Worth, Fort Worth, TX (US);
Abstract
Dopamine Dreceptor antagonists and partial agonists are known to modulate the reinforcing and drug-seeking effects induced by cocaine and other abused substances. By introducing functionality into the butylamide linking chain of the 4-phenylpiperazine class of ligands, improved Dreceptor affinity and selectivity, as well as water solubility, is achieved. A series of linking-chain derivatives are disclosed wherein functionality such as OH or OAc groups have been introduced into the linking chain. In general, these modifications are well tolerated at Dreceptors and achieve high selectivity over Dand Dreceptors.