The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Feb. 02, 2012
Wanxiang Xu, Shanghai, CN;
Shaohua Gu, Shanghai, CN;
Yaping He, Shanghai, CN;
Chaoneng Ji, Shanghai, CN;
Haiping Tang, Shanghai, CN;
Jian Wang, Shanghai, CN;
Zhida Sun, Shanghai, CN;
Yi Xie, Shanghai, CN;
Wanxiang Xu, Shanghai, CN;
Shaohua Gu, Shanghai, CN;
Yaping He, Shanghai, CN;
Chaoneng Ji, Shanghai, CN;
Haiping Tang, Shanghai, CN;
Jian Wang, Shanghai, CN;
Zhida Sun, Shanghai, CN;
Yi Xie, Shanghai, CN;
Hengsun Pharmaceutical Technology Co. Ltd., Guangzhou, CN;
Abstract
Minimal Motifs of linear B-cell epitopes in L1 structure protein from human papillomavirus type 58 (HPV 58) and their applications are disclosed. Eighteen linear epitope motifs and their extended 8-mer peptides in the L1 protein from HPV 58 are described, which can be used as antigens separately or in combination to specifically detect the serum from subjects with HPV 58 infection, or to develop preventive or therapeutic multi-epitope peptide vaccines against HPV 58 by inducing humoral immunity. Of the eighteen B-cell epitope motifs, ten of them are 100% conservative and one is highly conservative among many homologous proteins of high-risk HPVs. They can be used as candidate 'universal' epitopes to develop preventive or therapeutic HPV vaccines. The amino acid sequences of the epitope motifs and the 8-mer peptide formula of the invention are shown below in SEQ ID No. 1-2, 2B, 3, 3B, 4-18, 18B, 19, 19B, and 20-32.