The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2014
Filed:
Nov. 12, 2010
Piero Picci, San Lazzaro di Savena, IT;
Katia Scotlandi, Bologna, IT;
Alessandro Ascione, Rome, IT;
Maurizio Cianfriglia, Anzio, IT;
Maria Luisa Dupuis, Rome, IT;
Michela Flego, Rome, IT;
Mara Gellini, Rome, IT;
Alessandra Mallano, Rome, IT;
Piero Picci, San Lazzaro di Savena, IT;
Katia Scotlandi, Bologna, IT;
Alessandro Ascione, Rome, IT;
Maurizio Cianfriglia, Anzio, IT;
Maria Luisa Dupuis, Rome, IT;
Michela Flego, Rome, IT;
Mara Gellini, Rome, IT;
Alessandra Mallano, Rome, IT;
Istituto Ortopedico Rizzoli, Bologna, IL;
Abstract
The present invention relates to a single-chain variable fragment (scFv) able to recognize an epitope of the extracellular domain of CD99 human protein. The single-chain variable fragment is able to recognize and specifically and selectively bind the epitope of the extracellular domain of CD99 human protein expressed on Ewing sarcoma cells. The fragment can thus be used for the diagnosis and 10 treatment of Ewing sarcoma.