The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
May. 07, 2009
Cecilia Bastos, South Grafton, MA (US);
Michael L. Booker, Bridgewater, MA (US);
Cassandra A. Celatka, Hull, MA (US);
Jon C. Clardy, Jamaica Plain, MA (US);
Joseph Cortese, Quincy, MA (US);
Vishal P. Patel, Washington, DC (US);
Renato Skerlj, Newton, MA (US);
Roger C. Wiegand, Wayland, MA (US);
Dyann F. Wirth, Boston, MA (US);
Cecilia Bastos, South Grafton, MA (US);
Michael L. Booker, Bridgewater, MA (US);
Cassandra A. Celatka, Hull, MA (US);
Jon C. Clardy, Jamaica Plain, MA (US);
Joseph Cortese, Quincy, MA (US);
Vishal P. Patel, Washington, DC (US);
Renato Skerlj, Newton, MA (US);
Roger C. Wiegand, Wayland, MA (US);
Dyann F. Wirth, Boston, MA (US);
Genzyme Corporation, Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
Inhibitors of dihydroorotate dehydrogenase (DHODH) for theenzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.