The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Jan. 25, 2011
Isabel Kalofonos, Cambridge, MA (US);
G. Patrick Stahly, West Lafayette, IN (US);
William Martin-doyle, Cambridge, MA (US);
Dimitris Kalofonos, Cambridge, MA (US);
Jeffrey S. Stults, West Lafayette, IN (US);
Travis L. Houston, Lafayette, IN (US);
Isabel Kalofonos, Cambridge, MA (US);
G. Patrick Stahly, West Lafayette, IN (US);
William Martin-Doyle, Cambridge, MA (US);
Dimitris Kalofonos, Cambridge, MA (US);
Jeffrey S. Stults, West Lafayette, IN (US);
Travis L. Houston, Lafayette, IN (US);
Bionevia Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic.