The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Dec. 18, 2009
Richard D. Dimarchi, Carmel, IN (US);
Binbin Kou, Bloomington, IN (US);
Shujiang Cheng, Bloomington, IN (US);
Richard D. DiMarchi, Carmel, IN (US);
Binbin Kou, Bloomington, IN (US);
Shujiang Cheng, Bloomington, IN (US);
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Abstract
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.