The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Jun. 15, 2012
Jeffrey Stavenhagen, Brookville, MD (US);
Sergey Gorlatov, Gaithersburg, MD (US);
Christopher Rankin, Clarksburg, MD (US);
Nadine Tuaillon, Gaithersburg, MD (US);
Jeffrey Stavenhagen, Brookville, MD (US);
Sergey Gorlatov, Gaithersburg, MD (US);
Christopher Rankin, Clarksburg, MD (US);
Nadine Tuaillon, Gaithersburg, MD (US);
MacroGenics, Inc., Rockville, MD (US);
Abstract
The present invention relates to molecules comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are useful in preventing, treating, or ameliorating symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function mediated by FcγR is desired, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.